Methods
Reperfusion is defined as the relative Tmax >6s change (% of baseline).
Surrogates for good collateral flow in this study are:
* Degree of reperfusion in non-recanalizers
* The hypoperfusion intensity ration (HIR) at baseline (lower is better), defined according to:
Bang, O. Y. et al. (2008) âDeterminants of the distribution and severity of hypoperfusion in patients with ischemic stroke.â, Neurology
* The modified ASITN/SIR Collateral Flow Grading System (adapted for DSC-MRI, aka “Higashida score”), according to:
Campbell BC V, Christensen S, Tress BM, Churilov L, Desmond PM, Parsons MW, Alan Barber P, Levi CR, Bladin C, Donnan GA, Davis SM (2013) Failure of collateral blood flow is associated with infarct growth in ischemic stroke. J Cereb Blood Flow Metab and dichotomized into good (3-4) and poor (0-2) according to: Galinovic I, Kochova E, Khalil A, Villringer K, Piper SK, Fiebach JB (2018) The ratio between cerebral blood flow and Tmax predicts the quality of collaterals in acute ischemic stroke. PLoS One 13:e0190811
The outcome measures in this study are:
* Extent of reperfusion - relative Tmax >6s change (%)
* Modified Rankin Scale at Day 90
* Absolute infarct growth on DWI between days 1 and 2 (mL)
* Absolute infarct growth between days 1 (DWI) and 5 (FLAIR) (mL)
All regression analyses are performed using a robust GLM (“High Breakdown And High Efficiency Robust Linear Regression”) using the R function “lmrob” from the “robustbase” package.
Citation of package:
Martin Maechler, Peter Rousseeuw, Christophe Croux, Valentin Todorov, Andreas Ruckstuhl, Matias Salibian-Barrera, Tobias Verbeke, Manuel Koller, Eduardo L. T. Conceicao and Maria Anna di Palma (2018). robustbase: Basic Robust Statistics R package version 0.93-0. URL http://CRAN.R-project.org/package=robustbase
Citation of robust GLM:
Yohai, V. J. (1987). High breakdown-point and high efficiency robust estimates for regression. The Annals of Statistics, 642-656.
For visualization (not analysis) purposes, outliers are not shown on the boxplots.
Power analysis:
Sample size needed to detect a minimum effect size (R2/1-R2) of 0.1 at significance level of 0.05 and power of 0.8 with 8 predictors (including interactions) = 158. Performed with the R package “pwr”.
Citation of package:
Stephane Champely (2018). pwr: Basic Functions for Power Analysis. R package version 1.2-2. https://CRAN.R-project.org/package=pwr
Summary of main results
- Higashida score and recanalization are independent predictors of reperfusion. See Predictors of extent of reperfusion
- Collateral flow (HIR or Higashida score) does not predict reperfusion in full recanalizers. See [Predictors of extent of reperfusion in full recanalizers]
- Collateral flow (HIR or Higashida score) does not predict reperfusion in non-recanalizers. See [Predictors of extent of reperfusion in non-recanalizers]
- Higashida score independently predicts reperfusion in partial recanalizers. See [Predictors of extent of reperfusion in partial recanalizers]
- NIHSS on admission and recanalization independently predict 90 day mRS. Collateral flow and reperfusion do not. See Predictors of clinical outcome
- Collateral flow (both Higashida and HIR), NIHSS on admission, and reperfusion in partial recanalizers independently predict early infarct growth (D1 - D2). See Predictors of absolute infarct growth (D1 - D2)
- Collateral flow (both Higashida and HIR), NIHSS on admission, and reperfusion in partial recanalizers independently predict late infarct growth (D1 - D5). See Predictors of absolute infarct growth (D1 - D5)
Descriptive statistics
## Factors are dropped from the summary
|
|
N
|
Missing
|
|
Mean
|
SD
|
|
Min
|
Q1
|
Median
|
Q3
|
Max
|
|
ID
|
186
|
0
|
|
156.76
|
96.20
|
|
2.00
|
71.00
|
154.50
|
242.00
|
323.00
|
|
age
|
186
|
0
|
|
71.72
|
13.23
|
|
23.00
|
66.00
|
74.00
|
82.00
|
93.00
|
|
TSI
|
186
|
0
|
|
6.97
|
6.81
|
|
0.00
|
1.50
|
3.55
|
12.10
|
24.00
|
|
NIHSS_ad
|
186
|
0
|
|
8.28
|
6.33
|
|
0.00
|
3.00
|
6.00
|
13.00
|
25.00
|
|
NIHSS_dis
|
185
|
1
|
|
4.39
|
5.66
|
|
0.00
|
0.00
|
2.00
|
6.00
|
29.00
|
|
mRS_ad
|
176
|
10
|
|
3.03
|
1.47
|
|
0.00
|
2.00
|
3.00
|
4.00
|
5.00
|
|
mRS_dis
|
173
|
13
|
|
2.19
|
1.64
|
|
0.00
|
1.00
|
2.00
|
4.00
|
6.00
|
|
mRS_d90
|
149
|
37
|
|
2.30
|
1.92
|
|
0.00
|
1.00
|
2.00
|
4.00
|
6.00
|
|
DWIvol_d1
|
186
|
0
|
|
15.26
|
27.48
|
|
0.00
|
0.99
|
5.40
|
18.55
|
231.36
|
|
DWIvol_d2
|
186
|
0
|
|
31.18
|
49.31
|
|
0.00
|
3.07
|
12.39
|
39.64
|
324.01
|
|
Tmax_vol_d1
|
186
|
0
|
|
45.47
|
49.77
|
|
0.00
|
11.00
|
26.60
|
67.00
|
258.63
|
|
Tmax_vol_d2
|
186
|
0
|
|
26.83
|
85.47
|
|
0.00
|
1.00
|
7.00
|
27.50
|
1094.00
|
|
DWIgrowth
|
186
|
0
|
|
15.91
|
28.08
|
|
-1.34
|
0.72
|
5.28
|
14.74
|
178.68
|
|
rel_DWIgrowth
|
186
|
0
|
|
357.66
|
1268.39
|
|
-100.00
|
30.46
|
72.54
|
210.90
|
11561.11
|
|
Tmax_change
|
186
|
0
|
|
-23.94
|
42.72
|
|
-258.63
|
-37.00
|
-9.50
|
-1.00
|
104.80
|
|
relTmax_change
|
186
|
0
|
|
-29.35
|
143.98
|
|
-100.00
|
-95.56
|
-57.30
|
-7.69
|
1433.33
|
|
mismatch_vol
|
186
|
0
|
|
30.21
|
47.59
|
|
-119.36
|
0.84
|
16.76
|
53.16
|
253.40
|
|
infarct_growth_D5FLAIR
|
141
|
45
|
|
26.87
|
43.08
|
|
-3.68
|
1.97
|
8.50
|
29.69
|
222.72
|
|
FLAIR_d5_vol
|
141
|
45
|
|
41.57
|
57.20
|
|
0.01
|
5.90
|
18.50
|
55.50
|
300.40
|
|
Tmax_D1_.2_volume
|
186
|
0
|
|
83.28
|
60.82
|
|
1.05
|
33.30
|
72.75
|
120.61
|
317.11
|
|
Tmax_D1_.4_volume
|
186
|
0
|
|
64.04
|
57.58
|
|
0.14
|
19.03
|
46.88
|
93.02
|
317.11
|
|
Tmax_D1_.8_volume
|
186
|
0
|
|
27.50
|
34.79
|
|
0.00
|
2.82
|
12.70
|
38.68
|
172.25
|
|
Tmax_D2_.2_volume
|
186
|
0
|
|
48.02
|
53.07
|
|
0.00
|
8.02
|
30.91
|
62.36
|
281.54
|
|
Tmax_D2_.4_volume
|
186
|
0
|
|
32.84
|
44.49
|
|
0.00
|
2.41
|
16.44
|
40.61
|
226.83
|
|
Tmax_D2_.8_volume
|
186
|
0
|
|
11.60
|
21.45
|
|
0.00
|
0.08
|
1.62
|
14.76
|
130.90
|
|
HIR1
|
186
|
0
|
|
0.27
|
0.24
|
|
0.00
|
0.07
|
0.23
|
0.42
|
1.00
|
|
HIR2
|
178
|
8
|
|
0.18
|
0.24
|
|
0.00
|
0.01
|
0.07
|
0.29
|
1.00
|
|
Tmax_D1_.6_volume
|
186
|
0
|
|
45.47
|
49.77
|
|
0.00
|
11.00
|
26.60
|
67.00
|
258.63
|
|
Tmax_D2_.6_volume
|
186
|
0
|
|
26.83
|
85.47
|
|
0.00
|
1.00
|
7.00
|
27.50
|
1094.00
|
|
Tmax_6_reperf_abs
|
186
|
0
|
|
18.64
|
84.23
|
|
-966.10
|
1.00
|
9.00
|
37.00
|
258.63
|
|
Tmax_6_reperf_rel
|
180
|
6
|
|
26.05
|
157.55
|
|
-1433.33
|
11.09
|
66.18
|
96.09
|
100.00
|
## Level N %
## 1 higashida_D1 0 4 2.2
## 2 1 31 16.7
## 3 2 50 26.9
## 4 3 49 26.3
## 5 4 51 27.4
## 6 NaN 0 0.0
## 7 <Missing> 1 0.5
## 8 higashida_D2 0 3 1.6
## 9 1 22 11.8
## 10 2 38 20.4
## 11 3 39 21.0
## 12 4 81 43.5
## 13 NaN 0 0.0
## 14 <Missing> 3 1.6
## 15 Rekan None 67 36.0
## 16 Partial 64 34.4
## 17 Full 55 29.6
## 18 circulation Anterior 142 76.3
## 19 Posterior 44 23.7
## 20 sex Female 79 42.5
## 21 Male 107 57.5
## 22 iv_tPR No 106 57.0
## 23 Yes 80 43.0
Plot showing the change in Higashida scores over time for each patient.
Predictors of extent of reperfusion


|
|
|
|
Dependent variable:
|
|
|
|
|
|
Tmax_6_reperf_rel
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
|
|
|
NIHSS_ad
|
-0.605 (0.606)
|
-0.248 (0.563)
|
-0.225 (0.605)
|
0.257 (0.536)
|
|
|
t = -0.998
|
t = -0.440
|
t = -0.372
|
t = 0.479
|
|
|
p = 0.320
|
p = 0.661
|
p = 0.711
|
p = 0.633
|
|
iv_tPRYes
|
16.778** (7.372)
|
6.089 (7.200)
|
5.314 (7.271)
|
5.530 (6.700)
|
|
|
t = 2.276
|
t = 0.846
|
t = 0.731
|
t = 0.825
|
|
|
p = 0.025
|
p = 0.399
|
p = 0.466
|
p = 0.411
|
|
RekanPartial
|
|
26.774*** (7.780)
|
22.873* (12.077)
|
27.384*** (9.714)
|
|
|
|
t = 3.441
|
t = 1.894
|
t = 2.819
|
|
|
|
p = 0.001
|
p = 0.060
|
p = 0.006
|
|
RekanFull
|
|
43.999*** (8.495)
|
31.011** (13.239)
|
33.681*** (10.641)
|
|
|
|
t = 5.179
|
t = 2.342
|
t = 3.165
|
|
|
|
p = 0.00000
|
p = 0.021
|
p = 0.002
|
|
HIR1
|
|
|
-21.505 (25.723)
|
|
|
|
|
|
t = -0.836
|
|
|
|
|
|
p = 0.405
|
|
|
higashida_D1_binPoor
|
|
|
|
-24.774** (10.317)
|
|
|
|
|
|
t = -2.401
|
|
|
|
|
|
p = 0.018
|
|
circulationPosterior
|
-21.023** (8.773)
|
-15.293* (8.088)
|
-14.228* (8.132)
|
-11.229 (7.501)
|
|
|
t = -2.396
|
t = -1.891
|
t = -1.750
|
t = -1.497
|
|
|
p = 0.018
|
p = 0.061
|
p = 0.082
|
p = 0.137
|
|
RekanPartial:HIR1
|
|
|
14.252 (33.521)
|
|
|
|
|
|
t = 0.425
|
|
|
|
|
|
p = 0.672
|
|
|
RekanFull:HIR1
|
|
|
43.918 (36.192)
|
|
|
|
|
|
t = 1.213
|
|
|
|
|
|
p = 0.227
|
|
|
RekanPartial:higashida_D1_binPoor
|
|
|
|
-12.396 (14.319)
|
|
|
|
|
|
t = -0.866
|
|
|
|
|
|
p = 0.388
|
|
RekanFull:higashida_D1_binPoor
|
|
|
|
21.163 (14.861)
|
|
|
|
|
|
t = 1.424
|
|
|
|
|
|
p = 0.157
|
|
Constant
|
58.155*** (7.129)
|
36.180*** (7.879)
|
42.089*** (9.968)
|
45.000*** (8.405)
|
|
|
t = 8.158
|
t = 4.592
|
t = 4.222
|
t = 5.354
|
|
|
p = 0.000
|
p = 0.00001
|
p = 0.00004
|
p = 0.00000
|
|
|
|
Observations
|
180
|
180
|
180
|
180
|
|
R2
|
0.063
|
0.199
|
0.200
|
0.280
|
|
Adjusted R2
|
0.047
|
0.176
|
0.162
|
0.246
|
|
Residual Std. Error
|
46.630 (df = 176)
|
42.332 (df = 174)
|
42.418 (df = 171)
|
39.082 (df = 171)
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
1 vs 2
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
175.000
|
1.414
|
174
|
174.5
|
175.5
|
176
|
|
Test.Stat
|
1
|
27.943
|
|
27.943
|
27.943
|
27.943
|
27.943
|
|
Df
|
1
|
2.000
|
|
2.000
|
2.000
|
2.000
|
2.000
|
|
Pr(> chisq)
|
1
|
0.00000
|
|
0.00000
|
0.00000
|
0.00000
|
0.00000
|
|
|
1 vs 3
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
173.500
|
3.536
|
171
|
172.2
|
174.8
|
176
|
|
Test.Stat
|
1
|
28.640
|
|
28.640
|
28.640
|
28.640
|
28.640
|
|
Df
|
1
|
5.000
|
|
5.000
|
5.000
|
5.000
|
5.000
|
|
Pr(> chisq)
|
1
|
0.00003
|
|
0.00003
|
0.00003
|
0.00003
|
0.00003
|
|
|
1 vs 4
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
173.500
|
3.536
|
171
|
172.2
|
174.8
|
176
|
|
Test.Stat
|
1
|
50.570
|
|
50.570
|
50.570
|
50.570
|
50.570
|
|
Df
|
1
|
5.000
|
|
5.000
|
5.000
|
5.000
|
5.000
|
|
Pr(> chisq)
|
1
|
0.000
|
|
0.000
|
0.000
|
0.000
|
0.000
|
|
|
Predictors of extent of reperfusion
|
|
|
|
HIR
|
Higashida
|
|
NIHSS on admission
|
-0.225 (0.605)
|
0.257 (0.536)
|
|
|
t = -0.372
|
t = 0.479
|
|
|
p = 0.711
|
p = 0.633
|
|
IV tPA (yes)
|
5.314 (7.271)
|
5.530 (6.700)
|
|
|
t = 0.731
|
t = 0.825
|
|
|
p = 0.466
|
p = 0.411
|
|
Recanalization (partial)
|
22.873* (12.077)
|
27.384*** (9.714)
|
|
|
t = 1.894
|
t = 2.819
|
|
|
p = 0.060
|
p = 0.006
|
|
Recanalization (full)
|
31.011** (13.239)
|
33.681*** (10.641)
|
|
|
t = 2.342
|
t = 3.165
|
|
|
p = 0.021
|
p = 0.002
|
|
HIR
|
-21.505 (25.723)
|
|
|
|
t = -0.836
|
|
|
|
p = 0.405
|
|
|
Higashida (poor)
|
|
-24.774** (10.317)
|
|
|
|
t = -2.401
|
|
|
|
p = 0.018
|
|
Circulation (posterior)
|
-14.228* (8.132)
|
-11.229 (7.501)
|
|
|
t = -1.750
|
t = -1.497
|
|
|
p = 0.082
|
p = 0.137
|
|
Recanalization (partial)*HIR
|
14.252 (33.521)
|
|
|
|
t = 0.425
|
|
|
|
p = 0.672
|
|
|
Recanalization (full)*HIR
|
43.918 (36.192)
|
|
|
|
t = 1.213
|
|
|
|
p = 0.227
|
|
|
Recanalization (partial)*Higashida (poor)
|
|
-12.396 (14.319)
|
|
|
|
t = -0.866
|
|
|
|
p = 0.388
|
|
Recanalization (full)*Higashida (poor)
|
|
21.163 (14.861)
|
|
|
|
t = 1.424
|
|
|
|
p = 0.157
|
|
Constant
|
42.089*** (9.968)
|
45.000*** (8.405)
|
|
|
t = 4.222
|
t = 5.354
|
|
|
p = 0.00004
|
p = 0.00000
|
|
|
|
Observations
|
180
|
180
|
|
R2
|
0.200
|
0.280
|
|
Adjusted R2
|
0.162
|
0.246
|
|
Residual Std. Error (df = 171)
|
42.418
|
39.082
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
Predictors of clinical outcome



|
|
|
|
Dependent variable:
|
|
|
|
|
|
mRS_d90
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
(5)
|
(6)
|
|
|
|
NIHSS_ad
|
|
0.162*** (0.026)
|
|
0.165*** (0.026)
|
|
0.171*** (0.025)
|
|
|
|
t = 6.281
|
|
t = 6.378
|
|
t = 6.753
|
|
|
|
p = 0.000
|
|
p = 0.000
|
|
p = 0.000
|
|
iv_tPRYes
|
|
-0.526* (0.305)
|
|
-0.559* (0.307)
|
|
-0.565* (0.314)
|
|
|
|
t = -1.723
|
|
t = -1.820
|
|
t = -1.798
|
|
|
|
p = 0.088
|
|
p = 0.071
|
|
p = 0.075
|
|
RekanPartial
|
|
-0.979** (0.480)
|
|
-0.683 (0.432)
|
|
-0.923* (0.480)
|
|
|
|
t = -2.038
|
|
t = -1.581
|
|
t = -1.921
|
|
|
|
p = 0.044
|
|
p = 0.117
|
|
p = 0.057
|
|
RekanFull
|
|
-1.572*** (0.513)
|
|
-1.266*** (0.451)
|
|
-1.299** (0.550)
|
|
|
|
t = -3.066
|
|
t = -2.809
|
|
t = -2.364
|
|
|
|
p = 0.003
|
|
p = 0.006
|
|
p = 0.020
|
|
HIR1
|
2.110*** (0.722)
|
0.869 (1.078)
|
|
|
|
|
|
|
t = 2.922
|
t = 0.806
|
|
|
|
|
|
|
p = 0.005
|
p = 0.422
|
|
|
|
|
|
circulationPosterior
|
|
0.372 (0.313)
|
|
0.401 (0.313)
|
|
0.383 (0.319)
|
|
|
|
t = 1.188
|
|
t = 1.281
|
|
t = 1.200
|
|
|
|
p = 0.237
|
|
p = 0.203
|
|
p = 0.233
|
|
RekanPartial:HIR1
|
|
-0.307 (1.432)
|
|
|
|
|
|
|
|
t = -0.214
|
|
|
|
|
|
|
|
p = 0.831
|
|
|
|
|
|
RekanFull:HIR1
|
|
0.596 (1.553)
|
|
|
|
|
|
|
|
t = 0.384
|
|
|
|
|
|
|
|
p = 0.702
|
|
|
|
|
|
RekanPartial:higashida_D1_binPoor
|
|
|
|
-0.725 (0.652)
|
|
|
|
|
|
|
|
t = -1.113
|
|
|
|
|
|
|
|
p = 0.268
|
|
|
|
RekanFull:higashida_D1_binPoor
|
|
|
|
-0.151 (0.672)
|
|
|
|
|
|
|
|
t = -0.225
|
|
|
|
|
|
|
|
p = 0.823
|
|
|
|
higashida_D1_binPoor
|
|
|
1.035*** (0.328)
|
0.631 (0.464)
|
|
|
|
|
|
|
t = 3.152
|
t = 1.361
|
|
|
|
|
|
|
p = 0.002
|
p = 0.176
|
|
|
|
RekanPartial:Tmax_6_reperf_rel
|
|
|
|
|
|
-0.003 (0.006)
|
|
|
|
|
|
|
|
t = -0.418
|
|
|
|
|
|
|
|
p = 0.677
|
|
RekanFull:Tmax_6_reperf_rel
|
|
|
|
|
|
-0.002 (0.006)
|
|
|
|
|
|
|
|
t = -0.312
|
|
|
|
|
|
|
|
p = 0.756
|
|
Tmax_6_reperf_rel
|
|
|
|
|
-0.003 (0.002)
|
-0.0004 (0.002)
|
|
|
|
|
|
|
t = -1.568
|
t = -0.278
|
|
|
|
|
|
|
p = 0.120
|
p = 0.782
|
|
Constant
|
1.695*** (0.248)
|
1.664*** (0.379)
|
1.800*** (0.215)
|
1.539*** (0.358)
|
2.408*** (0.184)
|
1.902*** (0.322)
|
|
|
t = 6.845
|
t = 4.391
|
t = 8.385
|
t = 4.302
|
t = 13.104
|
t = 5.901
|
|
|
p = 0.000
|
p = 0.00003
|
p = 0.000
|
p = 0.00004
|
p = 0.000
|
p = 0.00000
|
|
|
|
Observations
|
149
|
149
|
149
|
149
|
144
|
144
|
|
R2
|
0.057
|
0.369
|
0.066
|
0.368
|
0.018
|
0.362
|
|
Adjusted R2
|
0.051
|
0.333
|
0.059
|
0.332
|
0.011
|
0.324
|
|
Residual Std. Error
|
1.959 (df = 147)
|
1.592 (df = 140)
|
1.946 (df = 147)
|
1.594 (df = 140)
|
1.997 (df = 142)
|
1.600 (df = 135)
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
1 vs 2
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
143.500
|
4.950
|
140
|
141.8
|
145.2
|
147
|
|
Test.Stat
|
1
|
66.264
|
|
66.264
|
66.264
|
66.264
|
66.264
|
|
Df
|
1
|
7.000
|
|
7.000
|
7.000
|
7.000
|
7.000
|
|
Pr(> chisq)
|
1
|
0.000
|
|
0.000
|
0.000
|
0.000
|
0.000
|
|
|
1 vs 3
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
143.500
|
4.950
|
140
|
141.8
|
145.2
|
147
|
|
Test.Stat
|
1
|
64.648
|
|
64.648
|
64.648
|
64.648
|
64.648
|
|
Df
|
1
|
7.000
|
|
7.000
|
7.000
|
7.000
|
7.000
|
|
Pr(> chisq)
|
1
|
0.000
|
|
0.000
|
0.000
|
0.000
|
0.000
|
|
|
1 vs 4
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
138.500
|
4.950
|
135
|
136.8
|
140.2
|
142
|
|
Test.Stat
|
1
|
70.073
|
|
70.073
|
70.073
|
70.073
|
70.073
|
|
Df
|
1
|
7.000
|
|
7.000
|
7.000
|
7.000
|
7.000
|
|
Pr(> chisq)
|
1
|
0.000
|
|
0.000
|
0.000
|
0.000
|
0.000
|
|
|
Predictors of long-term clinical outcome (mRS day 90)
|
|
|
|
HIR
|
Higashida
|
Reperfusion
|
|
NIHSS on admission
|
0.162*** (0.026)
|
0.165*** (0.026)
|
0.171*** (0.025)
|
|
|
t = 6.281
|
t = 6.378
|
t = 6.753
|
|
|
p = 0.000
|
p = 0.000
|
p = 0.000
|
|
IV tPA (yes)
|
-0.526* (0.305)
|
-0.559* (0.307)
|
-0.565* (0.314)
|
|
|
t = -1.723
|
t = -1.820
|
t = -1.798
|
|
|
p = 0.088
|
p = 0.071
|
p = 0.075
|
|
Recanalization (partial)
|
-0.979** (0.480)
|
-0.683 (0.432)
|
-0.923* (0.480)
|
|
|
t = -2.038
|
t = -1.581
|
t = -1.921
|
|
|
p = 0.044
|
p = 0.117
|
p = 0.057
|
|
Recanalization (full)
|
-1.572*** (0.513)
|
-1.266*** (0.451)
|
-1.299** (0.550)
|
|
|
t = -3.066
|
t = -2.809
|
t = -2.364
|
|
|
p = 0.003
|
p = 0.006
|
p = 0.020
|
|
HIR
|
0.869 (1.078)
|
|
|
|
|
t = 0.806
|
|
|
|
|
p = 0.422
|
|
|
|
Higashida (poor)
|
|
0.631 (0.464)
|
|
|
|
|
t = 1.361
|
|
|
|
|
p = 0.176
|
|
|
Reperfusion
|
|
|
-0.0004 (0.002)
|
|
|
|
|
t = -0.278
|
|
|
|
|
p = 0.782
|
|
Circulation (posterior)
|
0.372 (0.313)
|
0.401 (0.313)
|
0.383 (0.319)
|
|
|
t = 1.188
|
t = 1.281
|
t = 1.200
|
|
|
p = 0.237
|
p = 0.203
|
p = 0.233
|
|
Recanalization (partial)*HIR
|
-0.307 (1.432)
|
|
|
|
|
t = -0.214
|
|
|
|
|
p = 0.831
|
|
|
|
Recanalization (full)*HIR
|
0.596 (1.553)
|
|
|
|
|
t = 0.384
|
|
|
|
|
p = 0.702
|
|
|
|
Recanalization (partial)*Higashida (poor)
|
|
-0.725 (0.652)
|
|
|
|
|
t = -1.113
|
|
|
|
|
p = 0.268
|
|
|
Recanalization (full)*Higashida (poor)
|
|
-0.151 (0.672)
|
|
|
|
|
t = -0.225
|
|
|
|
|
p = 0.823
|
|
|
Recanalization (partial)*Reperfusion
|
|
|
-0.003 (0.006)
|
|
|
|
|
t = -0.418
|
|
|
|
|
p = 0.677
|
|
Recanalization (full)*Reperfusion
|
|
|
-0.002 (0.006)
|
|
|
|
|
t = -0.312
|
|
|
|
|
p = 0.756
|
|
Constant
|
1.664*** (0.379)
|
1.539*** (0.358)
|
1.902*** (0.322)
|
|
|
t = 4.391
|
t = 4.302
|
t = 5.901
|
|
|
p = 0.00003
|
p = 0.00004
|
p = 0.00000
|
|
|
|
Observations
|
149
|
149
|
144
|
|
R2
|
0.369
|
0.368
|
0.362
|
|
Adjusted R2
|
0.333
|
0.332
|
0.324
|
|
Residual Std. Error
|
1.592 (df = 140)
|
1.594 (df = 140)
|
1.600 (df = 135)
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
Predictors of absolute infarct growth (D1 - D2)



|
|
|
|
Dependent variable:
|
|
|
|
|
|
DWIgrowth
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
(5)
|
(6)
|
|
|
|
NIHSS_ad
|
|
0.413*** (0.108)
|
|
0.405*** (0.100)
|
|
0.615*** (0.120)
|
|
|
|
t = 3.820
|
|
t = 4.032
|
|
t = 5.132
|
|
|
|
p = 0.0002
|
|
p = 0.0001
|
|
p = 0.00000
|
|
iv_tPRYes
|
|
-0.067 (1.294)
|
|
-0.545 (1.233)
|
|
0.630 (1.469)
|
|
|
|
t = -0.052
|
|
t = -0.442
|
|
t = 0.429
|
|
|
|
p = 0.959
|
|
p = 0.659
|
|
p = 0.669
|
|
RekanPartial
|
|
-1.475 (1.990)
|
|
0.661 (1.645)
|
2.073 (1.482)
|
1.228 (1.628)
|
|
|
|
t = -0.741
|
|
t = 0.402
|
t = 1.398
|
t = 0.755
|
|
|
|
p = 0.460
|
|
p = 0.689
|
p = 0.164
|
p = 0.452
|
|
RekanFull
|
|
0.232 (2.093)
|
|
0.986 (1.775)
|
1.086 (2.185)
|
0.114 (2.497)
|
|
|
|
t = 0.111
|
|
t = 0.556
|
t = 0.497
|
t = 0.046
|
|
|
|
p = 0.912
|
|
p = 0.580
|
p = 0.620
|
p = 0.964
|
|
HIR1
|
13.157*** (2.364)
|
12.810*** (4.847)
|
|
|
|
|
|
|
t = 5.566
|
t = 2.643
|
|
|
|
|
|
|
p = 0.00000
|
p = 0.009
|
|
|
|
|
|
higashida_D1_binPoor
|
|
|
5.223*** (0.978)
|
7.024*** (1.918)
|
|
|
|
|
|
|
t = 5.340
|
t = 3.662
|
|
|
|
|
|
|
p = 0.00000
|
p = 0.0004
|
|
|
|
Tmax_6_reperf_rel
|
|
|
|
|
0.003 (0.008)
|
-0.002 (0.008)
|
|
|
|
|
|
|
t = 0.352
|
t = -0.245
|
|
|
|
|
|
|
p = 0.726
|
p = 0.807
|
|
circulationPosterior
|
0.169 (1.178)
|
1.114 (1.349)
|
-0.055 (1.094)
|
0.910 (1.269)
|
-0.451 (1.384)
|
1.400 (1.558)
|
|
|
t = 0.143
|
t = 0.826
|
t = -0.051
|
t = 0.717
|
t = -0.326
|
t = 0.898
|
|
|
p = 0.887
|
p = 0.410
|
p = 0.960
|
p = 0.475
|
p = 0.745
|
p = 0.371
|
|
RekanPartial:HIR1
|
|
2.420 (6.395)
|
|
|
|
|
|
|
|
t = 0.378
|
|
|
|
|
|
|
|
p = 0.706
|
|
|
|
|
|
RekanFull:HIR1
|
|
-4.650 (6.539)
|
|
|
|
|
|
|
|
t = -0.711
|
|
|
|
|
|
|
|
p = 0.478
|
|
|
|
|
|
RekanPartial:higashida_D1_binPoor
|
|
|
|
-2.160 (2.725)
|
|
|
|
|
|
|
|
t = -0.792
|
|
|
|
|
|
|
|
p = 0.430
|
|
|
|
RekanFull:higashida_D1_binPoor
|
|
|
|
-3.600 (2.643)
|
|
|
|
|
|
|
|
t = -1.362
|
|
|
|
|
|
|
|
p = 0.175
|
|
|
|
RekanPartial:Tmax_6_reperf_rel
|
|
|
|
|
-0.033*** (0.009)
|
-0.025** (0.010)
|
|
|
|
|
|
|
t = -3.691
|
t = -2.554
|
|
|
|
|
|
|
p = 0.0003
|
p = 0.012
|
|
RekanFull:Tmax_6_reperf_rel
|
|
|
|
|
-0.012 (0.024)
|
-0.012 (0.026)
|
|
|
|
|
|
|
t = -0.509
|
t = -0.478
|
|
|
|
|
|
|
p = 0.612
|
p = 0.634
|
|
Constant
|
2.526*** (0.840)
|
0.569 (1.573)
|
3.381*** (0.682)
|
0.623 (1.354)
|
5.990*** (1.158)
|
2.041 (1.537)
|
|
|
t = 3.006
|
t = 0.361
|
t = 4.957
|
t = 0.461
|
t = 5.173
|
t = 1.328
|
|
|
p = 0.004
|
p = 0.719
|
p = 0.00001
|
p = 0.646
|
p = 0.00000
|
p = 0.186
|
|
|
|
Observations
|
186
|
186
|
186
|
186
|
180
|
180
|
|
R2
|
0.135
|
0.222
|
0.128
|
0.212
|
0.176
|
0.258
|
|
Adjusted R2
|
0.126
|
0.187
|
0.118
|
0.176
|
0.147
|
0.223
|
|
Residual Std. Error
|
7.129 (df = 183)
|
7.554 (df = 177)
|
6.654 (df = 183)
|
7.267 (df = 177)
|
8.456 (df = 173)
|
8.693 (df = 171)
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
1 vs 2
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
180.000
|
4.243
|
177
|
178.5
|
181.5
|
183
|
|
Test.Stat
|
1
|
16.646
|
|
16.646
|
16.646
|
16.646
|
16.646
|
|
Df
|
1
|
6.000
|
|
6.000
|
6.000
|
6.000
|
6.000
|
|
Pr(> chisq)
|
1
|
0.011
|
|
0.011
|
0.011
|
0.011
|
0.011
|
|
|
1 vs 3
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
180.000
|
4.243
|
177
|
178.5
|
181.5
|
183
|
|
Test.Stat
|
1
|
19.266
|
|
19.266
|
19.266
|
19.266
|
19.266
|
|
Df
|
1
|
6.000
|
|
6.000
|
6.000
|
6.000
|
6.000
|
|
Pr(> chisq)
|
1
|
0.004
|
|
0.004
|
0.004
|
0.004
|
0.004
|
|
|
1 vs 4
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
172.000
|
1.414
|
171
|
171.5
|
172.5
|
173
|
|
Test.Stat
|
1
|
29.497
|
|
29.497
|
29.497
|
29.497
|
29.497
|
|
Df
|
1
|
2.000
|
|
2.000
|
2.000
|
2.000
|
2.000
|
|
Pr(> chisq)
|
1
|
0.00000
|
|
0.00000
|
0.00000
|
0.00000
|
0.00000
|
|
|
Predictors of early infarct growth
|
|
|
|
HIR
|
Higashida
|
Reperfusion
|
|
NIHSS on admission
|
0.413*** (0.108)
|
0.405*** (0.100)
|
0.615*** (0.120)
|
|
|
t = 3.820
|
t = 4.032
|
t = 5.132
|
|
|
p = 0.0002
|
p = 0.0001
|
p = 0.00000
|
|
IV tPA (yes)
|
-0.067 (1.294)
|
-0.545 (1.233)
|
0.630 (1.469)
|
|
|
t = -0.052
|
t = -0.442
|
t = 0.429
|
|
|
p = 0.959
|
p = 0.659
|
p = 0.669
|
|
Recanalization (partial)
|
-1.475 (1.990)
|
0.661 (1.645)
|
1.228 (1.628)
|
|
|
t = -0.741
|
t = 0.402
|
t = 0.755
|
|
|
p = 0.460
|
p = 0.689
|
p = 0.452
|
|
Recanalization (full)
|
0.232 (2.093)
|
0.986 (1.775)
|
0.114 (2.497)
|
|
|
t = 0.111
|
t = 0.556
|
t = 0.046
|
|
|
p = 0.912
|
p = 0.580
|
p = 0.964
|
|
HIR
|
12.810*** (4.847)
|
|
|
|
|
t = 2.643
|
|
|
|
|
p = 0.009
|
|
|
|
Higashida (poor)
|
|
7.024*** (1.918)
|
|
|
|
|
t = 3.662
|
|
|
|
|
p = 0.0004
|
|
|
Reperfusion
|
|
|
-0.002 (0.008)
|
|
|
|
|
t = -0.245
|
|
|
|
|
p = 0.807
|
|
Circulation (posterior)
|
1.114 (1.349)
|
0.910 (1.269)
|
1.400 (1.558)
|
|
|
t = 0.826
|
t = 0.717
|
t = 0.898
|
|
|
p = 0.410
|
p = 0.475
|
p = 0.371
|
|
Recanalization (partial)*HIR
|
2.420 (6.395)
|
|
|
|
|
t = 0.378
|
|
|
|
|
p = 0.706
|
|
|
|
Recanalization (full)*HIR
|
-4.650 (6.539)
|
|
|
|
|
t = -0.711
|
|
|
|
|
p = 0.478
|
|
|
|
Recanalization (partial)*Higashida (poor)
|
|
-2.160 (2.725)
|
|
|
|
|
t = -0.792
|
|
|
|
|
p = 0.430
|
|
|
Recanalization (full)*Higashida (poor)
|
|
-3.600 (2.643)
|
|
|
|
|
t = -1.362
|
|
|
|
|
p = 0.175
|
|
|
Recanalization (partial)*Reperfusion
|
|
|
-0.025** (0.010)
|
|
|
|
|
t = -2.554
|
|
|
|
|
p = 0.012
|
|
Recanalization (full)*Reperfusion
|
|
|
-0.012 (0.026)
|
|
|
|
|
t = -0.478
|
|
|
|
|
p = 0.634
|
|
Constant
|
0.569 (1.573)
|
0.623 (1.354)
|
2.041 (1.537)
|
|
|
t = 0.361
|
t = 0.461
|
t = 1.328
|
|
|
p = 0.719
|
p = 0.646
|
p = 0.186
|
|
|
|
Observations
|
186
|
186
|
180
|
|
R2
|
0.222
|
0.212
|
0.258
|
|
Adjusted R2
|
0.187
|
0.176
|
0.223
|
|
Residual Std. Error
|
7.554 (df = 177)
|
7.267 (df = 177)
|
8.693 (df = 171)
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
Predictors of absolute infarct growth (D1 - D5)



|
|
|
|
Dependent variable:
|
|
|
|
|
|
infarct_growth_D5FLAIR
|
|
|
(1)
|
(2)
|
(3)
|
(4)
|
(5)
|
(6)
|
|
|
|
NIHSS_ad
|
|
1.146*** (0.253)
|
|
1.064*** (0.238)
|
|
1.536*** (0.271)
|
|
|
|
t = 4.530
|
|
t = 4.468
|
|
t = 5.671
|
|
|
|
p = 0.00002
|
|
p = 0.00002
|
|
p = 0.00000
|
|
iv_tPRYes
|
|
0.052 (2.774)
|
|
0.557 (2.688)
|
|
0.652 (3.062)
|
|
|
|
t = 0.019
|
|
t = 0.207
|
|
t = 0.213
|
|
|
|
p = 0.986
|
|
p = 0.837
|
|
p = 0.832
|
|
RekanPartial
|
|
-1.135 (4.278)
|
|
-0.057 (3.656)
|
10.059*** (3.475)
|
6.325* (3.411)
|
|
|
|
t = -0.265
|
|
t = -0.016
|
t = 2.894
|
t = 1.854
|
|
|
|
p = 0.792
|
|
p = 0.988
|
p = 0.005
|
p = 0.067
|
|
RekanFull
|
|
-0.028 (4.646)
|
|
-0.262 (3.923)
|
-1.055 (5.183)
|
-2.898 (5.167)
|
|
|
|
t = -0.006
|
|
t = -0.067
|
t = -0.203
|
t = -0.561
|
|
|
|
p = 0.996
|
|
p = 0.947
|
p = 0.840
|
p = 0.576
|
|
HIR1
|
23.701*** (5.822)
|
17.653* (10.182)
|
|
|
|
|
|
|
t = 4.071
|
t = 1.734
|
|
|
|
|
|
|
p = 0.0001
|
p = 0.086
|
|
|
|
|
|
higashida_D1_binPoor
|
|
|
10.572*** (2.429)
|
9.345** (4.001)
|
|
|
|
|
|
|
t = 4.352
|
t = 2.335
|
|
|
|
|
|
|
p = 0.00003
|
p = 0.022
|
|
|
|
Tmax_6_reperf_rel
|
|
|
|
|
0.014 (0.017)
|
0.004 (0.016)
|
|
|
|
|
|
|
t = 0.859
|
t = 0.271
|
|
|
|
|
|
|
p = 0.393
|
p = 0.787
|
|
circulationPosterior
|
-1.105 (2.822)
|
1.295 (2.850)
|
-1.399 (2.668)
|
0.503 (2.717)
|
-2.640 (3.236)
|
1.360 (3.210)
|
|
|
t = -0.392
|
t = 0.454
|
t = -0.524
|
t = 0.185
|
t = -0.816
|
t = 0.424
|
|
|
p = 0.696
|
p = 0.651
|
p = 0.601
|
p = 0.854
|
p = 0.417
|
p = 0.673
|
|
RekanPartial:HIR1
|
|
2.813 (13.503)
|
|
|
|
|
|
|
|
t = 0.208
|
|
|
|
|
|
|
|
p = 0.836
|
|
|
|
|
|
RekanFull:HIR1
|
|
-10.734 (14.885)
|
|
|
|
|
|
|
|
t = -0.721
|
|
|
|
|
|
|
|
p = 0.473
|
|
|
|
|
|
RekanPartial:higashida_D1_binPoor
|
|
|
|
4.994 (5.807)
|
|
|
|
|
|
|
|
t = 0.860
|
|
|
|
|
|
|
|
p = 0.392
|
|
|
|
RekanFull:higashida_D1_binPoor
|
|
|
|
-4.928 (5.757)
|
|
|
|
|
|
|
|
t = -0.856
|
|
|
|
|
|
|
|
p = 0.394
|
|
|
|
RekanPartial:Tmax_6_reperf_rel
|
|
|
|
|
-0.117*** (0.019)
|
-0.099*** (0.019)
|
|
|
|
|
|
|
t = -6.084
|
t = -5.302
|
|
|
|
|
|
|
p = 0.000
|
p = 0.00000
|
|
RekanFull:Tmax_6_reperf_rel
|
|
|
|
|
-0.017 (0.055)
|
0.002 (0.053)
|
|
|
|
|
|
|
t = -0.309
|
t = 0.043
|
|
|
|
|
|
|
p = 0.758
|
p = 0.966
|
|
Constant
|
6.649*** (2.082)
|
1.133 (3.254)
|
7.762*** (1.723)
|
1.265 (2.969)
|
12.834*** (2.733)
|
2.635 (3.235)
|
|
|
t = 3.193
|
t = 0.348
|
t = 4.504
|
t = 0.426
|
t = 4.697
|
t = 0.814
|
|
|
p = 0.002
|
p = 0.729
|
p = 0.00002
|
p = 0.671
|
p = 0.00001
|
p = 0.417
|
|
|
|
Observations
|
141
|
141
|
141
|
141
|
138
|
138
|
|
R2
|
0.115
|
0.257
|
0.129
|
0.301
|
0.490
|
0.579
|
|
Adjusted R2
|
0.102
|
0.212
|
0.116
|
0.259
|
0.466
|
0.552
|
|
Residual Std. Error
|
14.323 (df = 138)
|
14.158 (df = 132)
|
13.614 (df = 138)
|
13.483 (df = 132)
|
16.765 (df = 131)
|
16.086 (df = 129)
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
1 vs 2
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
135.000
|
4.243
|
132
|
133.5
|
136.5
|
138
|
|
Test.Stat
|
1
|
24.668
|
|
24.668
|
24.668
|
24.668
|
24.668
|
|
Df
|
1
|
6.000
|
|
6.000
|
6.000
|
6.000
|
6.000
|
|
Pr(> chisq)
|
1
|
0.0004
|
|
0.0004
|
0.0004
|
0.0004
|
0.0004
|
|
|
1 vs 3
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
135.000
|
4.243
|
132
|
133.5
|
136.5
|
138
|
|
Test.Stat
|
1
|
31.061
|
|
31.061
|
31.061
|
31.061
|
31.061
|
|
Df
|
1
|
6.000
|
|
6.000
|
6.000
|
6.000
|
6.000
|
|
Pr(> chisq)
|
1
|
0.00002
|
|
0.00002
|
0.00002
|
0.00002
|
0.00002
|
|
|
1 vs 4
|
|
|
Statistic
|
N
|
Mean
|
St. Dev.
|
Min
|
Pctl(25)
|
Pctl(75)
|
Max
|
|
|
|
pseudoDf
|
2
|
130.000
|
1.414
|
129
|
129.5
|
130.5
|
131
|
|
Test.Stat
|
1
|
35.581
|
|
35.581
|
35.581
|
35.581
|
35.581
|
|
Df
|
1
|
2.000
|
|
2.000
|
2.000
|
2.000
|
2.000
|
|
Pr(> chisq)
|
1
|
0.00000
|
|
0.00000
|
0.00000
|
0.00000
|
0.00000
|
|
|
Predictors of total infarct growth
|
|
|
|
HIR
|
Higashida
|
Reperfusion
|
|
NIHSS on admission
|
1.146*** (0.253)
|
1.064*** (0.238)
|
1.536*** (0.271)
|
|
|
t = 4.530
|
t = 4.468
|
t = 5.671
|
|
|
p = 0.00002
|
p = 0.00002
|
p = 0.00000
|
|
IV tPA (yes)
|
0.052 (2.774)
|
0.557 (2.688)
|
0.652 (3.062)
|
|
|
t = 0.019
|
t = 0.207
|
t = 0.213
|
|
|
p = 0.986
|
p = 0.837
|
p = 0.832
|
|
Recanalization (partial)
|
-1.135 (4.278)
|
-0.057 (3.656)
|
6.325* (3.411)
|
|
|
t = -0.265
|
t = -0.016
|
t = 1.854
|
|
|
p = 0.792
|
p = 0.988
|
p = 0.067
|
|
Recanalization (full)
|
-0.028 (4.646)
|
-0.262 (3.923)
|
-2.898 (5.167)
|
|
|
t = -0.006
|
t = -0.067
|
t = -0.561
|
|
|
p = 0.996
|
p = 0.947
|
p = 0.576
|
|
HIR
|
17.653* (10.182)
|
|
|
|
|
t = 1.734
|
|
|
|
|
p = 0.086
|
|
|
|
Higashida (poor)
|
|
9.345** (4.001)
|
|
|
|
|
t = 2.335
|
|
|
|
|
p = 0.022
|
|
|
Reperfusion
|
|
|
0.004 (0.016)
|
|
|
|
|
t = 0.271
|
|
|
|
|
p = 0.787
|
|
Circulation (posterior)
|
1.295 (2.850)
|
0.503 (2.717)
|
1.360 (3.210)
|
|
|
t = 0.454
|
t = 0.185
|
t = 0.424
|
|
|
p = 0.651
|
p = 0.854
|
p = 0.673
|
|
Recanalization (partial)*HIR
|
2.813 (13.503)
|
|
|
|
|
t = 0.208
|
|
|
|
|
p = 0.836
|
|
|
|
Recanalization (full)*HIR
|
-10.734 (14.885)
|
|
|
|
|
t = -0.721
|
|
|
|
|
p = 0.473
|
|
|
|
Recanalization (partial)*Higashida (poor)
|
|
4.994 (5.807)
|
|
|
|
|
t = 0.860
|
|
|
|
|
p = 0.392
|
|
|
Recanalization (full)*Higashida (poor)
|
|
-4.928 (5.757)
|
|
|
|
|
t = -0.856
|
|
|
|
|
p = 0.394
|
|
|
Recanalization (partial)*Reperfusion
|
|
|
-0.099*** (0.019)
|
|
|
|
|
t = -5.302
|
|
|
|
|
p = 0.00000
|
|
Recanalization (full)*Reperfusion
|
|
|
0.002 (0.053)
|
|
|
|
|
t = 0.043
|
|
|
|
|
p = 0.966
|
|
Constant
|
1.133 (3.254)
|
1.265 (2.969)
|
2.635 (3.235)
|
|
|
t = 0.348
|
t = 0.426
|
t = 0.814
|
|
|
p = 0.729
|
p = 0.671
|
p = 0.417
|
|
|
|
Observations
|
141
|
141
|
138
|
|
R2
|
0.257
|
0.301
|
0.579
|
|
Adjusted R2
|
0.212
|
0.259
|
0.552
|
|
Residual Std. Error
|
14.158 (df = 132)
|
13.483 (df = 132)
|
16.086 (df = 129)
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
Predictors of collateral flow defined by Higashida score
|
|
|
|
Dependent variable:
|
|
|
|
|
|
higashida_D1_bin
|
|
|
|
NIHSS_ad
|
0.038 (0.035)
|
|
|
t = 1.093
|
|
|
p = 0.275
|
|
age
|
0.003 (0.016)
|
|
|
t = 0.204
|
|
|
p = 0.839
|
|
sexMale
|
0.754* (0.407)
|
|
|
t = 1.852
|
|
|
p = 0.065
|
|
TSI
|
-0.022 (0.028)
|
|
|
t = -0.793
|
|
|
p = 0.428
|
|
DWIvol_d1
|
0.081*** (0.020)
|
|
|
t = 3.974
|
|
|
p = 0.0001
|
|
circulationPosterior
|
-0.018 (0.432)
|
|
|
t = -0.042
|
|
|
p = 0.967
|
|
Constant
|
-1.855 (1.242)
|
|
|
t = -1.494
|
|
|
p = 0.136
|
|
|
|
Observations
|
186
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|
Predictors of collateral flow defined by HIR
|
|
|
|
Dependent variable:
|
|
|
|
|
|
HIR1
|
|
|
|
NIHSS_ad
|
0.038 (0.030)
|
|
|
t = 1.256
|
|
|
p = 0.210
|
|
age
|
0.012 (0.014)
|
|
|
t = 0.820
|
|
|
p = 0.412
|
|
sexMale
|
0.104 (0.373)
|
|
|
t = 0.278
|
|
|
p = 0.781
|
|
TSI
|
-0.015 (0.027)
|
|
|
t = -0.560
|
|
|
p = 0.576
|
|
DWIvol_d1
|
0.008 (0.006)
|
|
|
t = 1.166
|
|
|
p = 0.244
|
|
circulationPosterior
|
-0.143 (0.429)
|
|
|
t = -0.334
|
|
|
p = 0.739
|
|
Constant
|
-2.071* (1.149)
|
|
|
t = -1.803
|
|
|
p = 0.072
|
|
|
|
Observations
|
186
|
|
|
|
Note:
|
p<0.1; p<0.05; p<0.01
|